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KMID : 0604520110370030237
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 3 p.237 ~ p.245
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Effect of Inonotus obliquus Extract on the Expression MMPs and HAS-2
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Lee So-Hun
Park Sun-Hee
Lee Kang-Hyuk
Park Soo-Jin
Kim Young-Heui
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Abstract
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In order to investigate the possibility of Inonotus obliquus extract as an active ingredient for wrinkle-care cosmetics, we prepared 70 % ethanolic extract of Inonotus obliquus and measured its DPPH radical scavenging activity and elastase inhibitory activity. We also evaluated the effect of Inonotus obliquus extract on expression of MMPs and HAS-2 in fibroblast and HaCaT cell, respectively. Inonotus Obliquus extract showed DPPH radical scavenging activity and elastase inhibitory activity in a dose-dependant manner (SC50= 91 μg/mL, IC50=124 μg/mL). Inonotus obliquus extract inhibited the expression of MMP-1 mRNA 50 ~ 79 % at concentrations of 5 ~ 25 μg/mL, and reduced the expression of MMP-2 around 20 % at a concentration of 10 μg/mL. And it also reduced the expression of MMP-9 54 ~ 70 % in tconcentrations of 5 to 25 μg/mL. Furthermore, Inonotus obliquus extract increased HAS-2 mRNA expression in a dose-dependent manner in concentrations of 5 to 25 μg/mL without cytotoxicity. These results suggested that Inonotus Obliquus extract could be useful as an active ingredient for wrinkle-care cosmetics.
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KEYWORD
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Inonotus obliquus, antioxidant, anti-wrinkle, MMPs, HAS-2
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